Patterning of the chick forebrain anlage by the prechordal plate. Retinoid signalling in the development of the central nervous system. Fibroblast growth factor signalling during early vertebrate development. Initial patterning of the central nervous system: how many organizers? Nature Rev. Neural induction: toward a unifying mechanism. Shaping the vertebrate body plan by polarized embryonic cell movements. The vertebrate organizer (Springer, Berlin, Heidelberg, 2003). Spemann's organizer: models and molecules. The establishment of Spemann's organizer and patterning of the vertebrate embryo. Nodal is upstream of the orthogonal activity gradients of Wnt and BMP, which specify the anterior–posterior and dorsal–ventral axes the three growth-factor pathways cross-regulate each other.ĭe Robertis, E. In zebrafish, the tail organizer is composed of cells from the dorsal as well as the ventral side of the gastrula-stage embryo.ĭuring embryonic axis formation, BMP, Nodal and Wnt growth factors act in signalling gradients to pattern embryonic cells in a dose-dependent fashion. The tail organizer requires activity of BMP, Nodal and Wnt growth factors. The trunk organizer requires inhibition of BMP growth factors and expresses a corresponding set of BMP antagonists. The head organizer requires inhibition of BMP, Nodal and Wnt growth factors and expresses a corresponding set of growth-factor antagonists. Recent evidence indicates that both models apply.
They have different cell compositions and express distinct genes.Ī long-standing question is whether the regionally specific inductions of the Spemann–Mangold organizer are the result of quantitative or qualitative mechanisms. Head, trunk and tail organizers can be distinguished on the basis of transplantation experiments in all vertebrates. It coordinates pattern formation along the anterior–posterior, dorsal–ventral and left–right axes. The Spemann–Mangold organizer is an axis-inducing centre that is evolutionarily conserved in vertebrates.
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